Article
The switch region on Leishmania major chromosome 1 is not required for mitotic stability or gene expression, but appears to be essential.
Nucleic acids research - 1 Sept 2002
Dubessay Pascal, Ravel Christophe, Bastien Patrick, Crobu Lucien, Dedet Jean-Pierre, Pagès Michel, Blaineau Christine
Abstract excerpt
The Leishmania genome project reference strain, Leishmania major Friedlin, is trisomic for chromosome 1. The complete sequence of this chromosome has revealed that the genes are grouped into two large clusters of the polycistronic type, each borne by one DNA strand and located on each side of a 1.6-kb sequence often termed the switch region. Several hypotheses concerning the role of this switch region have been...
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