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Article

The Drosophila Hox gene deformed sculpts head morphology via direct regulation of the apoptosis activator reaper.

Cell - 23 Aug 2002

Lohmann Ingrid, McGinnis Nadine, Bodmer Morana, McGinnis William

Abstract excerpt

Hox proteins control morphological diversity along the anterior-posterior body axis of animals, but the cellular processes they directly regulate are poorly understood. We show that during early Drosophila development, the Hox protein Deformed (Dfd) maintains the boundary between the maxillary and mandibular head lobes by activating localized apoptosis. Dfd accomplishes this by directly activating the cell death...

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PMID: 12202035
DOI: 10.1016/s0092-8674(02)00871-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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