Article
Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure.
AIDS research and human retroviruses - 10 Aug 2002
Antinori Andrea, Zaccarelli Mauro, Cingolani Antonella, Forbici Federica, Rizzo Maria G, Trotta Maria P, Di Giambenedetto Simona, Narciso Pasquale, Ammassari Adriana, Girardi Enrico, De Luca Andrea, Perno Carlo F
Abstract excerpt
Heterogeneity in genotype mutations associated with resistance of HIV to nonnucleoside reverse transcriptase inhibitors (NNRTIs) should allow identification of patients failing nevirapine (NVP) who might benefit from efavirenz (EFV)-containing salvage regimens. To establish the feasibility of recycling EFV after failure of NVP-containing regimens genotypic data on 103 NVP-failed patients were analyzed to evaluate...
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