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Article

Hill-Robertson interference is a minor determinant of variations in codon bias across Drosophila melanogaster and Caenorhabditis elegans genomes.

Molecular biology and evolution - 1 Sept 2002

Marais Gabriel, Piganeau Gwenaël

Abstract excerpt

According to population genetics models, genomic regions with lower crossing-over rates are expected to experience less effective selection because of Hill-Robertson interference (HRi). The effect of genetic linkage is thought to be particularly important for a selection of weak intensity such as selection affecting codon usage. Consistent with this model, codon bias correlates positively with recombination rate...

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PMID: 12200468
DOI: 10.1093/oxfordjournals.molbev.a004203

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