The Hill-Robertson effect: evolutionary consequences of weak selection and linkage in finite populations.

doi:10.1038/sj.hdy.6801059

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Article

The Hill-Robertson effect: evolutionary consequences of weak selection and linkage in finite populations.

Heredity - 1 Jan 2008

Comeron J M, Williford A, Kliman R M

Abstract excerpt

The 'Hill-Robertson (HR) effect' describes that linkage between sites under selection will reduce the overall effectiveness of selection in finite populations. Here we discuss the major concepts associated with the HR effect and present results of computer simulations focusing on the linkage effects generated by multiple sites under weak selection. Most models of linkage and selection forecast differences in...

Topics

Animals
Computer Simulation
Drosophila melanogaster
Genetic Drift
Genetic Linkage
Genetic Variation
Genetics, Population
Linkage Disequilibrium
Mutation
Polymorphism, Genetic
Recombination, Genetic
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 17878920
DOI: 10.1038/sj.hdy.6801059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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