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Human Papillomavirus Type 16 Intratypic Variant Infection and Risk for Cervical Neoplasia in Southern China

1 Sept 2002

Abstract excerpt

A case-control study was conducted on 1986 Hong Kong women to assess the risk of human papillomavirus (HPV) type 16 variants for cervical neoplasia. In total, 255 women were HPV-16 positive and were analyzed for E6 and E7 sequence variation. Two novel substitutions at E6 (T86I and Q116E) and 1 at E7 (R66W) were found. Most HPV-16 variants were of Asian (50.6%) or European (44.3%) lineage, and both lineages showed...

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PMID: 12195358
DOI: 10.1086/342048

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