Article
Molecular variants of HPV-16 associated with cervical cancer in Indian population.
International journal of cancer - 1 Jul 2009
Pillai M R, Hariharan R, Babu Janki Mohan, Lakshmi S, Chiplunkar S V, Patkar M, Tongaonkar H, Dinshaw K, Jayshree R S, Reddy B K M, Siddiqui M, Roychoudury Soma, Saha Baisakhi, Abraham P, Gnanamony M, Peedicayil A, Subhashini J, Ram T S, Dey Bindu, Sharma C, Jain S K, Singh N
Abstract excerpt
Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progression. The objective of this multicentric study was to identify HPV-16 E6, E7 and L1 variants...
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