Article
Acetylsalicylic acid inhibits hepatitis C virus RNA and protein expression through cyclooxygenase 2 signaling pathways.
Hepatology (Baltimore, Md.) - 1 May 2008
Trujillo-Murillo Karina, Rincón-Sánchez Ana Rosa, Martínez-Rodríguez Herminia, Bosques-Padilla Francisco, Ramos-Jiménez Javier, Barrera-Saldaña Hugo A, Rojkind Marcos, Rivas-Estilla Ana María
Abstract excerpt
UNLABELLED: It has been reported that salicylates (sodium salicylate and aspirin) inhibit the replication of flaviviruses, such as Japanese encephalitis virus and dengue virus. Therefore, we considered it important to test whether acetylsalicylic acid (ASA) had anti-hepatitis C virus (HCV) activity. To this end, we examined the effects of ASA on viral replication and protein expression, using an HCV subgenomic...
Topics
- Aspirin
- Carcinoma, Hepatocellular
- Cell Line, Tumor
- Cyclooxygenase 2
- Genotype
- Hepacivirus
- Humans
- Liver Neoplasms
- Luciferases
- RNA, Neoplasm
- RNA, Viral
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction