Article
Evidence for a susceptibility gene (SLEH1) on chromosome 11q14 for systemic lupus erythematosus (SLE) families with hemolytic anemia.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2002
Kelly Jennifer A, Thompson Kevin, Kilpatrick Jeff, Lam Tom, Nath Swapan K, Gray-McGuire Courtney, Reid Jeff, Namjou Bahram, Aston Christopher E, Bruner Gail R, Scofield R Hal, Harley John B
Abstract excerpt
Hemolytic anemia is a forme fruste of systemic lupus erythematosus (SLE), being observed months or even years before the onset of other clinical manifestations in some patients. We hypothesized that hemolytic anemia in those SLE-affected patients would identify a group of SLE pedigrees that share a high degree of genetic homogeneity. From 160 multiplex SLE pedigrees, we sought evidence for linkage in 35 (16...
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