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Article

On the use of familial aggregation in population-based case probands for calculating penetrance.

Journal of the National Cancer Institute - 21 Aug 2002

Begg Colin B

Abstract excerpt

BACKGROUND: Estimating the lifetime risk associated with (i.e., the penetrance of) genetic abnormalities that predispose individuals to cancer is important for genetic counseling. (Penetrance may be estimated from the degree of familial aggregation of cancer, that is, the extent to which cancers cluster in families.) Early penetrance studies of BRCA1 and BRCA2 mutations used high-risk families with multiple cases...

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Source

Identifiers

PMID: 12189225
DOI: 10.1093/jnci/94.16.1221

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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