Article
Multiplicative genetic effects in scrapie disease susceptibility.
Comptes rendus biologies - 1 May 2002
Dubois Marc-Antoine, Sabatier Philippe, Durand Benoît, Calavas Didier, Ducrot Christian, Chalvet-Monfray Karine
Abstract excerpt
Despite experimental evidence that scrapie is an infectious disease of sheep, variations of the occurrence of the natural disease suggest an influence of host genetic factors. It has been established that the genetic polymorphism of the prion protein (PrP) gene is correlated to the incidence of scrapie and to the survival time: five polymorphisms have been described by variations at amino-acid codons 136, 154 and...
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