Article
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.
Nature medicine - 1 Sept 2002
Weijzen Sanne, Rizzo Paola, Braid Mike, Vaishnav Radhika, Jonkheer Suzanne M, Zlobin Andrei, Osborne Barbara A, Gottipati Sridevi, Aster Jon C, Hahn William C, Rudolf Michael, Siziopikou Kalliopi, Kast W Martin, Miele Lucio
Abstract excerpt
Truncated Notch receptors have transforming activity in vitro and in vivo. However, the role of wild-type Notch signaling in neoplastic transformation remains unclear. Ras signaling is deregulated in a large fraction of human malignancies and is a major target for the development of novel cancer treatments. We show that oncogenic Ras activates Notch signaling and that wild-type Notch-1 is necessary to maintain...
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