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Article

Decompensated hemorrhage activates serotonergic neurons in the subependymal parapyramidal region of the rat medulla.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2002

Pelaez Nicole M, Schreihofer Ann M, Guyenet Patrice G

Abstract excerpt

According to prior evidence opioid and serotonin release by lower brain stem neurons may contribute to hemorrhage-induced sympathoinhibition (HISI). Here we seek direct evidence for the activation of opioidergic, GABAergic, or serotonergic neurons by severe hemorrhage in the medulla oblongata. Blood was withdrawn from awake rats (40-50% total volume) causing hypotension and profound initial bradycardia. Other...

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Identifiers

PMID: 12185004
DOI: 10.1152/ajpregu.00154.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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