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Article

Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.

Sleep - 1 Jan 2015

Garrity Abigail G, Botta Simhadri, Lazar Stephanie B, Swor Erin, Vanini Giancarlo, Baghdoyan Helen A, Lydic Ralph

Abstract excerpt

STUDY OBJECTIVES: Dexmedetomidine is used clinically to induce states of sedation that have been described as homologous to nonrapid eye movement (NREM) sleep. A better understanding of the similarities and differences between NREM sleep and dexmedetomidine-induced sedation is essential for efforts to clarify the relationship between these two states. This study tested the hypothesis that dexmedetomidine-induced...

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Identifiers

PMID: 25325438
DOI: 10.5665/sleep.4328
PMCID: PMC4262959

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