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Article

Enhancement of closed-state inactivation in long QT syndrome sodium channel mutation DeltaKPQ.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2002

Chen Tiehua, Sheets Michael F

Abstract excerpt

DeltaKPQ, a three amino acid [lysine (K), proline (P), glutamine (Q)] deletion mutation of the human cardiac Na channel (hH1), which is one cause of long QT syndrome (LQT3), has impaired inactivation resulting in a late sodium current. To better understand inactivation in DeltaKPQ, we applied a site-3 toxin anthopleurin A, which has been shown to inhibit inactivation from the open state with little or no effect...

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Identifiers

PMID: 12181125
DOI: 10.1152/ajpheart.00097.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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