Article
[Study of PGM mutation mechanism in Yersinia pestis (plague pathogen) vaccine strain EV76].
Molekuliarnaia genetika, mikrobiologiia i virusologiia - 1 Jan 2002
Podladchikova O N, Rykova V A, Ivanova V S, Eremenko N S, Lebedeva S A
Abstract excerpt
Yersinia pestis vaccine strain EV76 is a mutant of the virulent strain which has lost the pigmentation phenotype (Pgm+). This phenotype includes three characteristics: it absorbs pigments from agar media (Hms+), produces a siderophore yersiniabactin (Ybt+), and causes a lethal disease after subcutaneous inoculation of laboratory animals (Vir+). These characteristics are lost simultaneously after high frequency...
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