Article
Is a polymorphism of the apolipoprotein E gene associated with preeclampsia?
Hypertension in pregnancy - 1 Jan 2002
Francoual Jeanne, Audibert François, Trioche Pascale, Chalas Jacqueline, Capel Liliane, Lindenbaum Albert, Labrune Philippe, Frydman René
Abstract excerpt
OBJECTIVE: Apolipoprotein E (apo E) is pivotal in lipid metabolism. In women with preeclampsia, an atherogenic state is observed. We hypothesized that a particular genotype of apo E may be associated with preeclampsia. METHODS: Genomic DNA was extracted from 55 normotensive and 49 preeclamptic women (defined according to the American College of Obstetricians and Gynecologists criteria). DNA was amplified by PCR...
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