Article
ACE gene polymorphism and renal scar in children with acute pyelonephritis.
Pediatric nephrology (Berlin, Germany) - 1 Jul 2002
Cho Su Jin, Lee Seung Joo
Abstract excerpt
The pathogenesis of renal scarring after acute pyelonephritis (APN) in children is multifactorial. In addition to well-known risk factors (young age, high grade of vesicoureteral reflux, P-fimbriated Escherichia coli, and treatment delay), a role for genetic predisposition has been suggested. Since the ACE gene deletion polymorphism is a known risk factor for progressive glomerulosclerosis in chronic renal...
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