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Article

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding.

The EMBO journal - 15 Aug 2002

Matsuo Michinori, Dabrowski Michael, Ueda Kazumitsu, Ashcroft Frances M

Abstract excerpt

ATP-sensitive potassium (K(ATP)) channels are composed of an ATP-binding cassette (ABC) protein (SUR1, SUR2A or SUR2B) and an inwardly rectifying K(+) channel (Kir6.1 or Kir6.2). Like other ABC proteins, the nucleotide binding domains (NBDs) of SUR contain a highly conserved "signature sequence" (the linker, LSGGQ) whose function is unclear. Mutation of the conserved serine to arginine in the linker of NBD1 (S1R)...

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Identifiers

PMID: 12169627
DOI: 10.1093/emboj/cdf419
PMCID: PMC125404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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