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Article

Cytotoxicity of dihydropteroate in Saccharomyces cerevisiae.

FEMS microbiology letters - 6 Aug 2002

Bayly Ann M, Macreadie Ian G

Abstract excerpt

Microbes and plants synthesise folate using a unique biosynthetic pathway that is absent in animals. The end product, tetrahydrofolate, is utilised by all forms of life. In this study, an intermediate in this synthesis, dihydropteroic acid, was found to be toxic to Saccharomyces cerevisiae. Further tests were performed on mutants deficient in folate synthesis. One mutant specifically lacked dihydropteroate...

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Identifiers

PMID: 12167536
DOI: 10.1111/j.1574-6968.2002.tb11304.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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