Article
Estrogen metabolism in human colorectal cancer cells.
The Journal of steroid biochemistry and molecular biology - 1 Jul 2002
Fiorelli G, Picariello L, Martineti V, Tognarini I, Tonelli F, Brandi M L
Abstract excerpt
Epidemiological and "in vitro" studies support a direct role of estrogens in the pathogenesis and/or progression of colorectal cancer (CRC). Recent observations suggest a local synthesis of 17beta-estradiol (E(2)). In the present study, the CRC estrogen receptor beta (ERbeta) positive HCT8, HCT116, DLD-1 and LoVo cell lines were evaluated for expression of functional 17beta-hydroxysteroid dehydrogenase...
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