Article
Helicobacter pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia.
Cytokine - 7 Jun 2002
Zambon C-F, Basso D, Navaglia F, Germano G, Gallo N, Milazzo M, Greco E, Fogar P, Mazza S, Di Mario F, Basso G, Rugge M, Plebani M
Abstract excerpt
Helicobacter pylori infection outcome might depend on genotypic polymorphisms of both the bacterium and the host. We ascertained: (1) the functionality of H. pylori oipA gene; (2) the polymorphism of the hostinterleukin (IL-1beta) gene (-31 C/T) and of the IL-1RN gene (intron 2 VNTR); (3) the association between the above genes and the histological and pathological outcome of H. pylori infection. One hundred and...
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