Article
Abnormal vertebral segmentation and the notch signaling pathway in man.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2007
Turnpenny Peter D, Alman Ben, Cornier Alberto S, Giampietro Philip F, Offiah Amaka, Tassy Olivier, Pourquié Olivier, Kusumi Kenro, Dunwoodie Sally
Abstract excerpt
Abnormal vertebral segmentation (AVS) in man is a relatively common congenital malformation but cannot be subjected to the scientific analysis that is applied in animal models. Nevertheless, some spectacular advances in the cell biology and molecular genetics of somitogenesis in animal models have proved to be directly relevant to human disease. Some advances in our understanding have come through DNA linkage...
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