<i>KRIT1</i> , a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein

Abstract excerpt

Mutations in Krev1 interaction trapped gene 1 (KRIT1) cause cerebral cavernous malformation, an autosomal dominant disease featuring malformation of cerebral capillaries resulting in cerebral hemorrhage, strokes, and seizures. The biological functions of KRIT1 are unknown. We have investigated KRIT1 expression in endothelial cells by using specific anti-KRIT1 antibodies. By both microscopy and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Intracerebral and Subarachnoid Hemorrhage Research
• Share to Intracranial Aneurysms: Treatment and Complications
• Share to Vascular Malformations Diagnosis and Treatment