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Article

Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Serebriiskii Ilya G, Elmekawy Mohamed, Golemis Erica A

Abstract excerpt

Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system that is associated with leaky capillaries, and a predisposition to serious clinical conditions including intracerebral hemorrhage and seizures. Germline or sporadic mutations in the CCM1/KRIT1 gene are responsible for the majority of cases of CCM. In this article, we describe the original characterization of the...

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Identifiers

PMID: 32524559
DOI: 10.1007/978-1-0716-0640-7_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System.PMID 32524559Read ↗

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Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1).Semantic proximity Read ↗

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