Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System.

doi:10.1007/978-1-0716-0640-7_20

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Article

Identification of the KRIT1 Protein by LexA-Based Yeast Two-Hybrid System.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Serebriiskii Ilya G, Elmekawy Mohamed, Golemis Erica A

Abstract excerpt

Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system that is associated with leaky capillaries, and a predisposition to serious clinical conditions including intracerebral hemorrhage and seizures. Germline or sporadic mutations in the CCM1/KRIT1 gene are...

Topics

Genetic Association Studies
Genotype
Hemangioma, Cavernous, Central Nervous System
Humans
KRIT1 Protein
Mutation
Peptide Library
Protein Binding
Protein Interaction Mapping
Transformation, Genetic
Two-Hybrid System Techniques
Workflow

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