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Article

High Level Expression of Recombinant Porcine Coagulation Factor VIII

1 Oct 2002

Abstract excerpt

Recombinant human factor VIII expression levels, in vitro and in vivo, are significantly lower than levels obtained for other recombinant coagulation proteins. Here we describe the generation, high level expression and characterization of a recombinant B-domain-deleted porcine factor VIII molecule. Recombinant B-domain-deleted porcine factor VIII expression levels are 10- to 14-fold greater than recombinant...

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PMID: 12138172
DOI: 10.1074/jbc.m206959200

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