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Identification of Porcine Coagulation Factor VIII Domains Responsible for High Level Expression via Enhanced Secretion

1 Feb 2004

Abstract excerpt

Blood coagulation factor VIII has a domain structure designated A1-A2-B-ap-A3-C1-C2. Human factor VIII is present at low concentration in normal plasma and, comparably, is produced at low levels in vitro and in vivo using transgenic expression techniques. Heterologous expression of B domain-deleted porcine factor VIII in mammalian cell culture is significantly greater than B domain-deleted human or murine factor...

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PMID: 14660593
DOI: 10.1074/jbc.m312451200

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