Article
Multiplex SNP genotyping in pooled DNA samples by a four-colour microarray system.
Nucleic acids research - 15 Jul 2002
Lindroos Katarina, Sigurdsson Snaevar, Johansson Karin, Rönnblom Lars, Syvänen Ann-Christine
Abstract excerpt
We selected 125 candidate single nucleotide polymorphisms (SNPs) in genes belonging to the human type 1 interferon (IFN) gene family and the genes coding for proteins in the main type 1 IFN signalling pathway by screening databases and by in silico comparison of DNA sequences. Using quantitative analysis of pooled DNA samples by solid-phase mini-sequencing, we found that only 20% of the candidate SNPs were...
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