Article
Imprinted genes: identification by chromosome rearrangements and post-genomic strategies.
Trends in genetics : TIG - 1 Jul 2002
Oakey Rebecca J, Beechey Colin V
Abstract excerpt
Imprinted genes are differentially expressed from the maternally and paternally inherited alleles. Accordingly, inheritance of both copies of an imprinted chromosome or region from a single parent leads to the mis-expression of the imprinted genes present in the selected region. Strains of mice with reciprocal and Robertsonian chromosomal translocations or mice with engineered chromosomal rearrangements can be...
Topics
- Animals
- Chromosomes
- DNA Methylation
- Gene Expression Profiling
- Gene Rearrangement
- Genomic Imprinting
- Humans
- Polymorphism, Single Nucleotide
- RNA, Antisense