Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The immune response to vaccinia virus is significantly reduced after scarification with TK- recombinants as compared to wild-type virus.

Acta virologica - 1 Jan 2000

Phillpotts R J, Lescott T, Gates A J, Jones L

Abstract excerpt

Although it is unlikely that large-scale vaccination against smallpox will ever be required again, it is conceivable that the need may arise to vaccinate against a human orthopoxvirus infection. A possible example could be the emergence of monkey poxvirus (MPV) as a significant human disease in Africa. Vaccinia virus (VV) recombinants, genetically modified to carry the immunogenic proteins of other pathogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Specificity
Share to Neutralization Tests

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to T-Lymphocytes, Cytotoxic

Share to Thymidine Kinase

Share to Vaccination

Share to Vaccines, Synthetic

Share to Vaccinia virus

Share to Viral Vaccines

Source

Identifiers

PMID: 11155357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The immune response to vaccinia virus is significantly reduced after scarification with TK- recombinants as compared to wild-type virus.PMID 11155357Read ↗

Genes that control vaccinia virus immunogenicitySemantic proximity Read ↗

Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.Semantic proximity Read ↗

The Evolution of Poxvirus VaccinesSemantic proximity Read ↗

Monkeypox virus and insights into its immunomodulatory proteinsSemantic proximity Read ↗

Active vaccination with vaccinia virus A33 protects mice against lethal vaccinia and ectromelia viruses but not against cowpoxvirus; elucidation of the specific adaptive immune response.Semantic proximity Read ↗

A study of the vaccinia virus interferon-γ receptor and its contribution to virus virulenceSemantic proximity Read ↗

Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralizationSemantic proximity Read ↗

Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype.Semantic proximity Read ↗

Recombinant chimeric Horsepox Virus (TNX-801) is attenuated relative to Vaccinia Virus Strains in Human Primary Cell Lines and in Immunocompromised MiceSemantic proximity Read ↗

Capturing the natural diversity of the human antibody response against vaccinia virus.Semantic proximity Read ↗

BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal ChallengeSemantic proximity Read ↗

A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.