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Article

Functional role of hCngb3 in regulation of human cone cng channel: effect of rod monochromacy-associated mutations in hCNGB3 on channel function.

Investigative ophthalmology & visual science - 1 Jul 2004

Okada Akira, Ueyama Hisao, Toyoda Futoshi, Oda Sanae, Ding Wei-Guang, Tanabe Shoko, Yamade Shinichi, Matsuura Hiroshi, Ohkubo Iwao, Kani Kazutaka

Abstract excerpt

PURPOSE: The human cone photoreceptor cyclic nucleotide-gated (CNG) channel comprises alpha- and beta-subunits, which are respectively encoded by hCNGA3 and hCNGB3. The purpose was to examine the functional role of hCNGB3 in modulation of human cone CNG channels and to characterize functional consequences of rod monochromacy-associated mutations in hCNGB3 (S435F and D633G). METHODS: Macroscopic patch currents...

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Identifiers

PMID: 15223812
DOI: 10.1167/iovs.03-1094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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