Article
Polymorphism of the vitamin D(3) receptor in patients with psoriasis.
Archives of dermatological research - 1 Jul 2002
Okita Hiroshi, Ohtsuka Tsutomu, Yamakage Akio, Yamazaki Soji
Abstract excerpt
1,25-Dihydroxyvitamin D is the biologically active form of vitamin D for the treatment of skin eruptions in patients with psoriasis. 1,25-(OH)(2)D(3) elicits its action on skin eruptions through the vitamin D receptor (VDR). Allelic frequencies of VDR were studied in 86 normal subjects and 50 patients with psoriasis. Genomic DNA was extracted from peripheral blood leukocytes and the VDR gene was amplified using a...
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