Article
Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients.
Archives of dermatological research - 1 Dec 2007
Dayangac-Erden Didem, Karaduman Aysen, Erdem-Yurter Hayat
Abstract excerpt
Psoriasis is characterized by hyperproliferation and abnormal differentiation of keratinocytes, and inflammation. 1,25-Dihydroxyvitamin D3, which is used for the treatment of psoriasis, binds to vitamin D receptor (VDR) and modulates gene transcription. We analyzed VDR gene FokI, ApaI and TaqI polymorphisms in 51 Turkish familial psoriasis patients (psoriasis vulgaris and psoriatic arthritis) and 100 healthy...
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