Article
Clustering of individuals with both breast and ovarian cancer--a possible indicator of BRCA founder mutations.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2002
Einbeigi Zakaria, Meis-Kindblom Jeanne M, Kindblom Lars-Gunnar, Wallgren Arne, Karlsson Per
Abstract excerpt
In a cohort of 60436 women with a diagnosis of invasive breast carcinoma and known to reside in Sweden in 1960, 321 had a subsequent diagnosis of ovarian carcinoma. Assuming no correlation between the two cancers, one would expect that 191 women would develop ovarian cancer (standardized incidence ratio (SIR) 1.7; 95% confidence interval 1.5-1.9). Women with breast cancer before 40 years of age were at highest...
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