Article
Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity.
Molecular and cellular biology - 1 Aug 2002
Moon Yang Soo, Smas Cynthia M, Lee Kichoon, Villena Josep A, Kim Kee-Hong, Yun Eun Jun, Sul Hei Sook
Abstract excerpt
Preadipocyte factor 1 (Pref-1/Dlk1) inhibits in vitro adipocyte differentiation and has been recently reported to be a paternally expressed imprinted gene at human chromosome 14q32. Studies on human chromosome 14 deletions and maternal uniparental disomy (mUPD) 14 suggest that misexpression of a yet-to-be-identified imprinted gene or genes present on chromosome 14 causes congenital disorders. We generated Pref-1...
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