Article
Codon 89 polymorphism in the human 5 alpha-reductase gene in primary breast cancer.
British journal of cancer - 23 Mar 2001
Scorilas A, Bharaj B, Giai M, Diamandis E P
Abstract excerpt
The enzyme human steroid 5-alpha reductase type II (SRD5A2) and androgen receptor (AR) are critical mediators of androgen action, suggesting a potential role in hormonally related cancers. The SRD5A2 gene harbours two frequent polymorphic sites, one in the coding region, at codon 89 of exon 1, where valine is substituted by leucine (V89L) and the other in the 3' untranslated region (3' UTR) where a variable...
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