Article
Cytotoxic T lymphocytes directed against a tumor-specific mutated antigen display similar HLA tetramer binding but distinct functional avidity and tissue distribution.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002
Echchakir Hamid, Dorothée Guillaume, Vergnon Isabelle, Menez Jeanne, Chouaib Salem, Mami-Chouaib Fathia
Abstract excerpt
We have previously identified an antigen (Ag) recognized on a human large cell carcinoma of the lung by a tumor-specific cytotoxic T lymphocyte clone derived from autologous tumor infiltrating lymphocytes (TILs). The antigenic peptide is presented by HLA-A2 molecules and is encoded by a mutated alpha-actinin-4 (ACTN4) gene. In the present report, we have isolated two anti-alpha-actinin-4 T cell clones from the...
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