Article
Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer.
Oncogene - 20 Jun 2002
Silva José M, Domínguez Gemma, González-Sancho José M, García José M, Silva Javier, García-Andrade Carmen, Navarro Antonia, Muñoz Alberto, Bonilla Félix
Abstract excerpt
The relation between thyroid status and diseases and cancer is unclear. No detailed analysis of thyroid hormone receptor (TR) expression in human breast cancer has been reported. We have analysed the expression and mutational status of the TRalpha1, encoded by the c-erbA proto-oncogene, TRbeta1 and TRbeta2 isoforms in 70 sporadic breast cancers. Alterations in the RNA level of TRbeta1, TRalpha1, or both were...
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