Article
Selective killing of cancer cells based on translational control of a suicide gene.
Cancer gene therapy - 1 Jul 2002
DeFatta Robert J, Li Yuan, De Benedetti Arrigo
Abstract excerpt
The translation initiation factor, eIF4E, is commonly overexpressed in solid tumors. This elevation allows for efficient translation of mRNA that are normally repressed by their 5' untranslated region, many of which encode growth-promoting proteins. This property was exploited to modulate the synthesis of HTK at the translational level to selectively kill cancer cells. Various breast cancer cell lines can...
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