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Article

SNT1/FRS2 mediates germinal vesicle breakdown induced by an activated FGF receptor1 in Xenopus oocytes.

The Journal of biological chemistry - 6 Sept 2002

Mood Kathleen, Friesel Robert, Daar Ira O

Abstract excerpt

The docking protein SNT1/FRS2 (fibroblast growth factor receptor substrate 2) is implicated in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR), which plays vital roles during embryogenesis. Activating FGFR mutations cause several craniosynostoses and dwarfism syndromes in humans. Here we show that the Xenopus homolog of mammalian FRS-2 (XFRS2) is essential for the...

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Source

Identifiers

PMID: 12082104
DOI: 10.1074/jbc.M203894200

Genes

FRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNT1/FRS2 mediates germinal vesicle breakdown induced by an activated FGF receptor1 in Xenopus oocytes.PMID 12082104Read ↗

FGF2/FGFR signaling promotes cumulus–oocyte complex maturation in vitroSemantic proximity Read ↗

FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus.Semantic proximity Read ↗

SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturationSemantic proximity Read ↗

The mouse seminal vesicle shape mutation is allelic with Fgfr2.Semantic proximity Read ↗

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.Semantic proximity Read ↗

Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites.Semantic proximity Read ↗

Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/β-catenin signalingSemantic proximity Read ↗

Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs.Semantic proximity Read ↗

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.Semantic proximity Read ↗

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.Semantic proximity Read ↗

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SNT-1/FRS2alpha physically interacts with Laloo and mediates mesoderm induction by fibroblast growth factor.Semantic proximity Read ↗

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