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FGF2/FGFR signaling promotes cumulus–oocyte complex maturation in vitro

19 Oct 2020

Abstract excerpt

Fibroblast growth factor 2 (FGF2), a member of FGF family, binds with FGF receptors (FGFR) to initiate biological functions in various somatic cells. However, little is known regarding the role of FGF2/FGFR on oocyte meiosis. In this study, we investigated expression patterns and functions of FGF2/FGFR during in vitro maturation (IVM) of mouse cumulus-oocyte complexes (COCs). Among four FGFRs, Ffgr1 was the most...

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PMID: 33434172
DOI: 10.1530/rep-20-0264

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