The structure of an allosamidin complex with the Coccidioides immitis chitinase defines a role for a second acid residue in substrate-assisted mechanism.

Abstract excerpt

Allosamidin is a known inhibitor of class 18 chitinases. We show that allosamidin is a competitive inhibitor of the fungal chitinase CiX1 from Coccidioides immitis, with a K(i) of 60 nM. We report the X-ray structure of the complex and show that upon inhibitor binding the side-chain of Asp169 rot...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acetylglucosamine
• Share to Aspartic Acid
• Share to Catalysis