Article
Escherichia coli genes involved in resistance to pyrazinoic acid, the active component of the tuberculosis drug pyrazinamide.
FEMS microbiology letters - 4 Jun 2002
Schaller Alain, Guo Ming, Gisanrin Oluwatosin, Zhang Ying
Abstract excerpt
The natural resistance of Escherichia coli to pyrazinoic acid (POA), the active derivative of pyrazinamide, was investigated. The TolC mutant was found to be more susceptible to POA and other weak acids than the wild-type strain. Mutation in EmrB but not AcrB efflux protein slightly increased POA susceptibility. Two transposon mutants with increased susceptibility to POA were found to harbor mutations in acnA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.