Article
Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.
The Biochemical journal - 1 Jul 2002
Brenneisen Peter, Wlaschek Meinhard, Schwamborn Edith, Schneider Lars-Alexander, Ma Wenjian, Sies Helmut, Scharffetter-Kochanek Karin
Abstract excerpt
Enhanced expression of matrix metalloproteinase (MMP)-1/interstitial collagenase and MMP-3/stromelysin-1 in skin fibroblasts and subsequent damage of dermal connective tissue in the context of sun-induced premature aging and skin tumour progression is causally linked to UVB irradiation. Here, we were interested in identifying components of the complex signal-transduction pathway underlying UVB-mediated...
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