Article
Applications of adhesion molecule gene knockout cell lines.
Methods in cell biology - 1 Jan 2002
Kreidberg Jordan A
Abstract excerpt
Cell lines derived from mice carrying targeted mutations in adhesion or ECM genes, and ES cell lines homozygous for mutations in these genes, have proved to be valuable tools to examine the functions of these molecules in development, and at a molecular level by in vitro experimentation. In many cases, the development of cell lines has exposed novel phenotypes not apparent from in vivo observations, possibly...
Topics
- Animals
- Cell Adhesion Molecules
- Cell Line
- Epithelial Cells
- Extracellular Matrix Proteins
- Fibroblasts
- Fibronectins
- Hematopoiesis
- Humans
- Integrins
- Keratinocytes
- Kidney
- Membrane Glycoproteins
- Mice
- Mice, Knockout
- Mutation
- Proteoglycans
- Stem Cells