Article
Ca(2+) and membrane binding to annexin 3 modulate the structure and dynamics of its N terminus and domain III.
Protein science : a publication of the Protein Society - 1 Jul 2002
Sopkova Jana, Raguenes-Nicol Céline, Vincent Michel, Chevalier Anne, Lewit-Bentley Anita, Russo-Marie Françoise, Gallay Jacques
Abstract excerpt
Annexin 3 (ANX A3) represents approximately 1% of the total protein of human neutrophils and promotes tight contact between membranes of isolated specific granules in vitro leading to their aggregation. Like for other annexins, the primary molecular events of the action of this protein is likely its binding to negatively charged phospholipid membranes in a Ca(2+)-dependent manner, via Ca(2+)-binding sites located...
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