Article
Characterization of Burkholderia pseudomallei infection and identification of novel virulence factors using a Caenorhabditis elegans host system.
Molecular microbiology - 1 Jun 2002
Gan Yunn-Hwen, Chua Kim Lee, Chua Hui Hoon, Liu Boping, Hii Chung Shii, Chong Hwee Ling, Tan Patrick
Abstract excerpt
The environmental saphrophyte Burkholderia pseudomallei is the causative agent of melioidosis, a systemic, potentially life-threatening condition endemic to many parts of south-east Asia and northern Australia. We have used the soil nematode Caenorhabditis elegans as a model host to characterize the mechanisms by which this bacterium mounts a successful infection. We find that C. elegans is susceptible to a broad...
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