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Article

PAI-1 promoter polymorphism modulates uPA-PAI complex accumulation by breast cancer cells.

Oncology - 1 Jan 2002

Alvarez-Millán J J, Bocos C, Ferrín V, Lucas A R, Ruibal A, Schneider J

Abstract excerpt

OBJECTIVES: The uPA-PAI system has been shown to play a role in the development of a more aggressive tumor phenotype. The PAI-1 promoter 4G/5G polymorphism, furthermore, regulates free plasma PAI-1 levels in patients with myocardial infarction. Our aim was to verify if the different polymorphisms in the PAI-1 promoter are also associated with alterations in the intracellular accumulation of uPA-PAI complexes in...

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Source

Identifiers

PMID: 12065877
DOI: 10.1159/000059577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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