Article
Assessment of virulence of uropathogenic Escherichia coli type 1 fimbrial mutants in which the invertible element is phase-locked on or off.
Infection and immunity - 1 Jul 2002
Gunther Nereus W, Snyder Jennifer A, Lockatell Virginia, Blomfield Ian, Johnson David E, Mobley Harry L T
Abstract excerpt
Type 1 fimbria is a proven virulence factor of uropathogenic Escherichia coli (UPEC), causing urinary tract infections. Expression of the fimbria is regulated at the transcriptional level by a promoter situated on an invertible element, which can exist in one of two different orientations. The orientation of the invertible element that allows the expression of type 1 fimbriae is defined as "on," and the opposite...
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