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Article

Integration of DNA ligation and rolling circle amplification for the homogeneous, end-point detection of single nucleotide polymorphisms.

Nucleic acids research - 15 Jun 2002

Pickering Judith, Bamford Anona, Godbole Varsha, Briggs Jackie, Scozzafava Giuseppe, Roe Phyllida, Wheeler Claire, Ghouze Firman, Cuss Sarah

Abstract excerpt

Association studies using common sequence variants or single nucleotide polymorphisms (SNPs) may provide a powerful approach to dissect the genetic inheritance of common complex traits. Such studies necessitate the development of cost-effective, high throughput technologies for scoring SNPs. The method described in this paper for the co-detection of both alleles of a SNP in a single homogeneous reaction combines...

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Identifiers

PMID: 12060698
DOI: 10.1093/nar/gnf060
PMCID: PMC117302

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